Terpenoid Therapeutics Inc. molecule is effective against pulmonary fibrosis in a mouse model

A novel small molecule in the Terpenoid Therapeutics Inc. (TTI) pipeline reduces the progression of pulmonary fibrosis in a mouse model that is accepted as a basis for human drug approval for this disease. The results are published as a manuscript titled “Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis,” which recently appeared in the journal Free Radical Biology and Medicine. Pulmonary fibrosis is a devastating disease with high morbidity and mortality. The innovative TTI compound affects an important signaling pathway in lung macrophages that reduces progression of the disease.

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Terpenoid Therapeutics Inc. molecule is effective prostate cancer metastasis in a mouse model

A novel small molecule in the Terpenoid Therapeutics Inc. (TTI) pipeline reduces metastases in a mouse model of prostate cancer. The results are published as a manuscript titled “Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis,” which recently appeared in the journal Clinical & Experimental Metastasis. Dr. Ray Hohl, Director of the Penn State Cancer Institute is the senior author. The data shows a 54% reduction in total adrenal tumor burden as compared to untreated controls. The innovative TTI compound affects an important signaling pathway which serves as a biomarker in these experiments.

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